邓春浩博士2021年毕业于澳门大学陈国凯教授实验室，研究方向为多能干细胞维持、分化及命运决定机制，近五年发表论文10篇，申请发明专利1项，研究内容包括甲状腺激素对多能干细胞维持及其对滋养层细胞分化的重要作用，胰岛素对细胞存活、细胞代谢及转录组的影响，脂类调控细胞代谢的分子机制及PKC信号通路对细胞分化的重要影响等。目前在珠海澳大科技研究院转化医学研发中心实验室从事人多能干细胞来源的人类皮肤角质形成细胞分化技术开发及其应用，同时参与建立珠海澳大科技研究院-南京艾尔普再生医学联合实验室，并进行人视网膜色素上皮退行性疾病干细胞治疗的相关研究。
参与的科研项目：
人类多能干细胞来源的低免疫原性通用型视网膜色素上皮细胞治疗老年黄斑部病变，澳门科学发展基金重点研发项目，2023.10-2026.09，项目合作负责人；
基于人诱导多能干细胞来源的视网膜色素上皮细胞治疗年龄相关性黄斑变性的药物筛选平台的建立，粤澳科技创新联合资助项目，2022.7-2025.6，项目合作负责人；
多能干细胞来源的角质形成细胞分化技术开发及应用，澳大华发联合实验室项目，2022.3-2025.2，主要参与人
获得奖项：
第七届“创客广东”生物医药与健康中小企业创新创业大赛，多能干细胞来源的三维皮肤模型的药物筛选平台简历，创客组优胜奖
2023年粤港澳大湾区高价值专利培育布局大赛，谱系来源正确的多能干细胞向角质形成细胞分化技术开发及应用，初创组五十强
发表论文：
Mingming Qin, Chunhao Deng, Liewei Wen, Guoqun Luo and Ya Meng, CRISPR-Cas and CRISPR-based screening system for precise gene editing and targeted cancer therapy, J Transl Med. 2024; 22: 516. doi: 10.1186/s12967-024-05235-2. (Co-first author)
Xiaomin Zhang, Limin Cheng, Chengqi Gao, Jing Chen, Shuangye Liao, Yongqiang Zheng, Liping Xu, Jingjing He, Danyang Wang, Ziqian Fang, Jianeng Zhang, Min Yan, Yi Luan, Siyu Chen, Li-Kun Chen, Xiaojun Xia, Chunhao Deng, Guokai Chen, Wende Li, Ze-Xian Liu, Penghui Zhou. Androgen Signaling Contributes to Sex Differences in Cancer by Inhibiting NF-κB Activation in T Cells and Suppressing Anti-Tumor Immunity. Cancer Res. 2023 Jan 12:CAN-22-2405. doi: 10.1158/0008-5472.
Chunhao Deng, Zhaoying Zhang, Faxiang Xu, Jiaqi Xu, Zhili Ren, Carlos Godoy-Parejo, Weiwei Liu, Zhou Zhou and Guokai Chen. Thyroid hormone enhances stem cell maintenance and promotes lineage-specific differentiation in human embryonic stem cells. Stem Cell Research & Therapy, 2022,13(1):120.
Carlos Godoy-Parejo, Chunhao Deng, Jiaqi Xu, Zhili Ren, Nana Ai, Weiwei Liu, Wei Ge, Chuxia Deng, Eugene Y Chin, Xiaoling Xu, Guokai Chen. Protein Kinase C Modulation Determines the Mesoderm/Extraembryonic Fate under BMP4 induction from Human Pluripotent Stem Cells. Stem Cells. 2023 Jun 15;41(6):578-591. doi: 10.1093/stmcls/sxad006.
Xiaoxiao Zhou, Zhili Ren, JiaQi Xu, Chunhao Deng, Carlos Godoy-Parejo, Faxiang Xu, Esther Chi Cheng Huang, Jiajia Wang, Zheyu Cai, Weiwei Liu, Guang Hu, Guokai Chen. Insulin directs dichotomous translational regulation to promote human embryonic stem cell survival and self-renewal. Int J Biol Sci 2022, 18(9):3562-3575.
Faxiang Xu, Chunhao Deng, Zhili Ren, Liangyu Sun, Ya Meng, Weiwei Liu, Jianbo Wan, Guokai Chen. Lysophosphatidic Acid Shifts Metabolic and Transcriptional Landscapes to Induce a Novel Cellular State in Human Pluripotent Stem Cells. Cell Reports, 2021,37(9):110063.
Zhili Ren, Hui Zhong, Chengcheng Song, Chunhao Deng, Hsun-Ting Hsieh, Weiwei Liu, Guokai Chen. Insulin Promotes Mitochondrial Respiration and Survival through PI3K/AKT/GSK3 Pathway in Human Embryonic Stem Cells. Stem Cell Reports, 2020 Dec 8,15(6):1362-1376.
Carlos Godoy-Parejo, Chunhao Deng, Yumeng Zhang, Weiwei Liu & Guokai Chen. Roles of vitamins in stem cells. Cellular and Molecular Life Sciences, 2020, volume 77, pages1771–1791.
Weiwei Liu, Chunhao Deng, Carlos Godoy-Parejo, Yumeng Zhang, Guokai Chen. Developments in cell culture systems for human pluripotent stem cells. World J Stem Cells, 2019, 11(11): 968-981
Carlos Godoy‐Parejo, Chunhao Deng, Weiwei Liu and Guokai Chen. Insulin Stimulates PI3K/AKT and Cell Adhesion to Promote the Survival of Individualized Human Embryonic Stem Cells. Stem Cells, 2019, Aug;37(8):1030-1041
Yang Yang, Zhili Ren, Faxiang Xu, Ya Meng, Yumeng Zhang, Nana Ai, Yan Long, Hio Ian Fok, Chunhao Deng, Xianyang Zhao, Liancheng Huang, Qi Zhao, Jiaxian Wang, Weiwei Liu, Wei Ge, and Guokai Chen. Endogenous IGF Signaling Directs Heterogeneous Mesoderm Differentiation in Human Embryonic Stem Cells. Cell Rep, 2019, Dec 10,29(11):3374-3384.e5.
Gou Weichao, Deng Chunhao, He Junhao, Chen Kunming. Progress and problems of hydrogen production by photosynthetic bacteria. Renewable Energy Resources, 2013, 31(2): 94−101.
Deng Chunhao, Sun Liangyu, Chen Kunming. Differences in Regulation of Photosynthetic Gene Expression Between Different Purple Bacteria. Biotechnology Bulletin, 2016, 32(2): 21-29.
Deng Chunhao, Gou Weichao, Sun Liangyu, Chen Kunming. Isolation and Identification of Anoxygenic Photosynthetic Bacteria and Quick Screening of Hydrogen Productive Strains. Acta Agriculturae Boreali-occidentalis Sinica, 2016. 25(8): 1187-1194.
联系方式
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